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- Title
Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine.
- Authors
Shimasaki, Takeo; Ishigaki, Yasuhito; Nakamura, Yuka; Takata, Takanobu; Nakaya, Naoki; Nakajima, Hideo; Sato, Itaru; Zhao, Xia; Kitano, Ayako; Kawakami, Kazuyuki; Tanaka, Takuji; Takegami, Tsutomu; Tomosugi, Naohisa; Minamoto, Toshinari; Motoo, Yoshiharu
- Abstract
Pancreatic cancer is obstinate and resistant to gemcitabine, a standard chemotherapeutic agent for the disease. We previously showed a therapeutic effect of glycogen synthase kinase-3β (GSK3β) inhibition against gastrointestinal cancer and glioblastoma. Here, we investigated the effect of GSK3β inhibition on pancreatic cancer cell sensitivity to gemcitabine and the underlying molecular mechanism.
- Publication
Journal of gastroenterology, 2012, Vol 47, Issue 3, p321
- ISSN
1435-5922
- Publication type
Journal Article
- DOI
10.1007/s00535-011-0484-9