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- Title
Cardiovascular and gastrointestinal events of three antiplatelet therapies: clopidogrel, clopidogrel plus proton-pump inhibitors, and aspirin plus proton-pump inhibitors in patients with previous gastrointestinal bleeding.
- Authors
Tsai, Yi-Wen; Wen, Yu-Wen; Huang, Weng-Foung; Chen, Pei-Fen; Kuo, Ken N; Hsiao, Fei-Yuan
- Abstract
Concomitant use of antiplatelet agents and proton-pump inhibitors (PPIs) has been recommended in patients with a history of gastrointestinal (GI) hemorrhage. However, recent studies have reported that PPIs may alter clopidogrel's pharmacokinetics and potentially lead to an increased risk of recurrent adverse cardiovascular (CV) events.
- Publication
Journal of gastroenterology, 2011, Vol 46, Issue 1, p39
- ISSN
1435-5922
- Publication type
Journal Article
- DOI
10.1007/s00535-010-0299-0