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- Title
Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity.
- Authors
Kondo, Yasuteru; Ueno, Yoshiyuki; Kakazu, Eiji; Kobayashi, Koju; Shiina, Masaaki; Tamai, Keiichi; Machida, Keigo; Inoue, Jun; Wakui, Yuta; Fukushima, Koji; Obara, Noriyuki; Kimura, Osamu; Shimosegawa, Tooru
- Abstract
Lymphotropic hepatitis C virus (HCV) infection of B and T cells might play an important role in the pathogenesis of hepatitis C. Recently, we showed that a lymphotropic HCV (SB strain) could infect established T-cell lines and B-cell lines. However, whether HCV replication interferes with cell proliferation and function in primary T lymphocytes is still unclear.
- Publication
Journal of gastroenterology, 2011, Vol 46, Issue 2, p232
- ISSN
1435-5922
- Publication type
Journal Article
- DOI
10.1007/s00535-010-0297-2