We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology.
- Authors
Caldwell, Stephen; Park, Sang H
- Abstract
The epidemiology of hepatocellular cancer (HCC) can be viewed from several important perspectives. The conventional perspective includes the overall public health impact of HCC, which is increasing in incidence in many regions of the world. The epidemiology of HCC can also be viewed from the perspective of variation in underlying disease associations such as viral hepatitis or the recently recognized link to nonalcoholic fatty liver disease (NAFLD). Of perhaps increasing importance with recent advances in therapy of HCC, the epidemiology of HCC can also be viewed from the perspective of variation in HCC biology. This lesser known perspective may depend in part on the underlying liver disease and the cell origin of the cancer, whether of hepatocyte or stem cell origin. This aspect is likely to become central to diagnosis and management of HCC with the further development of targeted therapeutics. The relative efficacy of these agents will likely depend on the biochemical pathways active in a given hepatocellular malignancy. This, in turn, is likely to be related to the epidemiological associations of HCC.
- Publication
Journal of gastroenterology, 2009, Vol 44 Suppl 19, p96
- ISSN
0944-1174
- Publication type
Journal Article
- DOI
10.1007/s00535-008-2258-6