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- Title
Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer.
- Authors
Yamagishi, Mariko; Noda, Masao; Tatsumi, Yoichi; Mukaisho, Ken-ichi; Mitsufuji, Shoji; Sugihara, Hiroyuki; Okanoue, Takeshi; Hattori, Takanori
- Abstract
Recent studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancer, and that cyclooxygenase-2 (COX-2) may be a target enzyme for the prevention or regression of cancer by the use of NSAIDs. Mucin histochemistry has made possible a clear distinction between the differentiated characteristics of gastrointestinal epithelial cells, and the possibility that phenotypic shifts from gastric- to intestinal-type in gastric carcinoma progression has been suggested. To evaluate the role of COX-2 in gastric cancer progression, we immunohistochemically investigated COX-2 expression, and examined its relationship to proliferative activity, mucin phenotype, and clinicopathological parameters in human advanced gastric carcinomas.
- Publication
Journal of gastroenterology, 2004, Vol 39, Issue 12, p1143
- ISSN
0944-1174
- Publication type
Journal Article
- DOI
10.1007/s00535-004-1463-1