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- Title
Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial.
- Authors
Jane Read; Dianne Volker; Narelle Smith; Annabel Childs
- Abstract
AbstractGoals??The aim of the study was to assess the impact of an eicosapentanoic acid-containing protein and energy dense oral nutritional supplement (EPA-ONS) on nutritional and inflammatory status, quality of life (QOL), plasma phospholipids (PPL) and cytokine profile, tolerance of irinotecan-containing chemotherapy and EPA-ONS in patients with advanced colorectal cancer (CRC) receiving chemotherapy.Materials and methods??Patients with advanced CRC having one prior chemotherapy regimen received 480?ml of EPA-ONS daily for 3?weeks before commencing chemotherapy with folinic acid, 5-fluorouracil, irinotecan (FOLFIRI), and continued for 3?cycles of treatment (9?weeks). All assessments including weight, body composition, C-reactive protein (CRP), QOL, dietary intake, PPL and cytokine analyses were performed at baseline, 3 and 9?weeks.Results??Twenty-three patients were enrolled, 20 completed 3?weeks, and 15 completed 9?weeks. The mean EPA-ONS intake was 1.7 tetrapaks (408?ml) daily. There was a significant increase in mean weight (2.5?kg) at 3?weeks (p?=?0.03). Lean body mass (LBM) was maintained. Protein and energy intake significantly decreased after the commencement of chemotherapy (proteinp?=?0.003, energyp?=?0.02). There was a significant increase in energy levels (p?=?0.03), whilst all other QOL measures were maintained. PPL EPA levels increased significantly over the first 3?weeks. Mean CRP increased by 14.9?mg/L over the first 3?weeks (p?=?0.004), but decreased to baseline levels by the end of the trial. There was a significant correlation between plasma IL-6 and IL-10 concentrations and survival, and between IL-12 and toxicity.Conclusion??Dietary counseling and the provision of EPA-ONS may result in maintenance of nutritional status and QOL, however randomized trials are required to evaluate the impact of EPA on toxicity from chemotherapy.
- Publication
Supportive Care in Cancer, 2007, Vol 15, Issue 3, p301
- ISSN
0941-4355
- Publication type
Academic Journal
- DOI
10.1007/s00520-006-0153-3