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- Title
Vitamin A deficiency associated with urinary retinol binding protein wasting in Dent's disease.
- Authors
Becker-Cohen, Rachel; Rinat, Choni; Ben-Shalom, Efrat; Feinstein, Sofia; Ivgi, Heftziba; Frishberg, Yaacov
- Abstract
Three patients with Dent's disease presented with complaints of impaired night vision or xerophthalmia and were found to have severely decreased serum retinol concentrations. Retinol, bound to its carrier retinol-binding protein (RBP), is filtered at the glomerulus and reabsorbed at the proximal tubule. We hypothesized that urinary loss of retinol-RBP complex is responsible for decreased serum retinol.
- Publication
Pediatric nephrology (Berlin, Germany), 2012, Vol 27, Issue 7, p1097
- ISSN
1432-198X
- Publication type
Journal Article
- DOI
10.1007/s00467-012-2121-0