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- Title
Glomerulocystic kidney disease.
- Authors
Bissler, John J; Siroky, Brian J; Yin, Hong
- Abstract
Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease.
- Publication
Pediatric nephrology (Berlin, Germany), 2010, Vol 25, Issue 10, p2049
- ISSN
1432-198X
- Publication type
Journal Article
- DOI
10.1007/s00467-009-1416-2