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- Title
Mechanistic insights into chromosome-wide silencing in X inactivation.
- Authors
Arthold, Susanne; Kurowski, Agata; Wutz, Anton
- Abstract
In mammals, one of the two X chromosomes in female cells is transcriptionally silenced for dosage compensation between the sexes. Chromosome-wide silencing is initiated by the non-coding Xist RNA that accumulates within the inactive X chromosome territory and triggers gene repression and chromatin modifications. Epigenetic changes of the inactive X chromosome in a developmentally regulated manner result in stable gene repression in female somatic cells. X inactivation is a model for understanding the formation of facultative heterochromatin in mammalian development and represents a paradigm for RNA mediated regulation of gene expression. In this review, we summarize the present knowledge of the mechanism of chromosome-wide silencing and give an outlook on future directions.
- Publication
Human genetics, 2011, Vol 130, Issue 2, p295
- ISSN
1432-1203
- Publication type
Journal Article
- DOI
10.1007/s00439-011-1002-0