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- Title
Contribution of the IBD5 locus to inflammatory bowel disease: a meta-analysis.
- Authors
Wang, Jian; Wang, Xi; Yang, Hong; Wu, Dong; Wang, Li; Qian, Jiaming
- Abstract
To evaluate the association of the IBD5 locus to the predisposition of inflammatory bowel diseases (IBDs), a series of meta-analyses between five IBD5 variants (OCTN1 C1672T, OCTN2 G-207C, OCTN1/2 TC haplotype, IGR2096a&#95;1, IGR2198a&#95;1 and IGR2230a&#95;1) and Crohn's disease (CD) and ulcerative colitis (UC) were performed, which included a total of 26 studies. Overall, five IBD5 variants in a per-allele model of inheritance were significantly associated with elevated CD risk (for OCTN1: OR = 1.23, 95% CI = 1.16-1.30, P < 0.001; for OCTN2: OR = 1.20, 95% CI = 1.11-1.30, P < 0.001; for IGR2096a&#95;1: OR = 1.36, 95% CI = 1.24-1.46, P < 0.001; for IGR2198a&#95;1: OR = 1.34, 95% CI = 1.24-1.46, P < 0.001; for IGR2230a&#95;1: OR = 1.35, 95% CI = 1.23-1.48, P < 0.001) and OCTN1/2 TC haplotype (OR = 1.32, 95% CI = 1.22-1.43, P < 0.001). In the subgroup analysis, the statistically significant associations were also observed in adult- and pediatric-onset CD and in Caucasians for five IBD5 variants and the OCTN1/2 TC haplotype. A statistically significant increase in the risk of UC was detected in a recessive model of inheritances for OCTN1 (OR = 1.23, 95% CI = 1.08-1.40, P < 0.001), OCTN2 (OR = 1.18, 95% CI = 1.05-1.33, P = 0.006), IGR2096a&#95;1 (OR = 1.37, 95% CI = 1.15-1.62, P < 0.001) and IGR2198a&#95;1 (OR = 1.35, 95% CI = 1.10-1.66, P = 0.004); the increased risks of UC were maintained in the adult and Caucasian subgroups, but not the pediatric subgroup. In summary, our results suggested that the IBD5 locus contributes to the susceptibility of CD in a per-allele manner in adults, children and Caucasians, and the locus contributes to the susceptibility of UC in a recessive manner in adult and Caucasian populations.
- Publication
Human genetics, 2011, Vol 129, Issue 6, p597
- ISSN
1432-1203
- Publication type
Journal Article
- DOI
10.1007/s00439-011-0952-6