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- Title
The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.
- Authors
Zogopoulous, George; Rothenmund, Heidi; Eppel, Ayelet; Ash, Colleen; Akbari, Mohammad Reza; Hedley, David; Narod, Steven A.; Gallinger, Steven
- Abstract
The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.
- Publication
Human Genetics, 2007, Vol 121, Issue 5, p635
- ISSN
0340-6717
- Publication type
Academic Journal
- DOI
10.1007/s00439-007-0361-z