We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The E3 ubiquitin ligase TRAF6 inhibits LPS-induced AKT activation in FLT3-ITD-positive MV4-11 AML cells.
- Authors
Schnetzke, Ulf; Fischer, Mike; Kuhn, Anne-Kathrin; Spies-Weisshart, Bärbel; Zirm, Elisabeth; Hochhaus, Andreas; Müller, Jörg P; Scholl, Sebastian
- Abstract
The aim of the study was to investigate the activation of the PI3K/AKT (phosphatidylinositol-3-kinase) pathway after stimulation of TLR-4 (Toll-like receptor 4) with LPS (lipopolysaccharide) in FLT3-ITD (internal tandem duplication)-positive AML (acute myeloid leukemia) cells. TRAF6 (tumor necrosis factor receptor-associated factor 6), an E3 ubiquitin ligase, is critically involved in TLR-signaling. Based on the observation that TRAF6 might play a role in AKT phosphorylation, we hypothesized that TRAF6 can enhance the constitutive FLT3-ITD-driven activation of AKT after LPS stimulation.
- Publication
Journal of cancer research and clinical oncology, 2013, Vol 139, Issue 4, p605
- ISSN
1432-1335
- Publication type
Journal Article
- DOI
10.1007/s00432-012-1362-4