We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo.
- Authors
Wang, Yong-Wei; Wang, Shuang-Jia; Zhou, Yi-Nan; Pan, Shang-Ha; Sun, Bei
- Abstract
Pancreatic cancer is an aggressive malignancy, which generally develops resistance to chemotherapy. Agents that are safe and can sensitize cancer to chemotherapy are urgently needed. Escin, a natural mixture of triterpene saponins isolated from Aesculus wilsonii Rehd, has been demonstrated to possess anti-cancer activity both in vitro and in vivo. The anti-cancer activity of escin could be, in part, due to the inactivation of nuclear factor-κB (NF-κB). In contrast, chemotherapy including gemcitabine could activate NF-κB and lead to chemoresistance. Here, for the first time, we investigated whether escin, via the inactivation of NF-κB, would potentiate the antitumor activity of gemcitabine in pancreatic cancer.
- Publication
Journal of cancer research and clinical oncology, 2012, Vol 138, Issue 5, p785
- ISSN
1432-1335
- Publication type
Journal Article
- DOI
10.1007/s00432-012-1152-z