We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy.
- Authors
Wilop, Stefan; von Hobe, Sabine; Crysandt, Martina; Esser, Albert; Osieka, Rainhardt; Jost, Edgar
- Abstract
The renin-angiotensin system plays a crucial role in maintaining vascular homeostasis. Stimulation of angiotensin II type 1 receptors (AT1R) acts proangiogenically by increasing levels of vascular endothelial growth factor (VEGF). Consequently, cell culture experiments and animal studies have shown antiproliferative effects of AT1R blockers (ARB) and angiotensin I converting enzyme inhibitors (ACEI) in several malignancies. Until now, very limited clinical data for this antiangiogenic effect exists for combinations with antineoplastic chemotherapy.
- Publication
Journal of cancer research and clinical oncology, 2009, Vol 135, Issue 10, p1429
- ISSN
1432-1335
- Publication type
Journal Article
- DOI
10.1007/s00432-009-0587-3