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- Title
Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer.
- Authors
Kim, Joo-Young; Shin, Hye-Jin; Kim, Tae-Hyun; Cho, Kwan-Ho; Shin, Kyung-Hwan; Kim, Bu-Kyoung; Roh, Ju-Won; Lee, Sun; Park, Sang-Yoon; Hwang, You-Jin; Han, Inn-Oc
- Abstract
Carbonic anhydrase IX (CA9) has emerged as an important surrogate marker for hypoxia in solid tumors. CA12 shares a role with CA9 in acidification of micromilieu but it is less strictly regulated by hypoxia than CA9. In this study, we investigated expression of CA9 and CA12 mRNA in primary cervical cancer. We also examined whether CA9 expression can be an indicator of reoxygenation of tumor by measuring its mRNA expression during fractionated radiotherapy.
- Publication
Journal of cancer research and clinical oncology, 2006, Vol 132, Issue 5, p302
- ISSN
0171-5216
- Publication type
Journal Article
- DOI
10.1007/s00432-005-0068-2