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- Title
Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.
- Authors
Tsukamoto, Tetsuya; Inada, Kenichi; Tanaka, Harunari; Mizoshita, Tsutomu; Mihara, Mami; Ushijima, Toshikazu; Yamamura, Yoshitaka; Nakamura, Shigeo; Tatematsu, Masae
- Abstract
The molecular mechanisms underlying the development of intestinal metaplasia (IM) of the human stomach have yet to be clarified in detail. Besides ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, little information is available regarding other regulatory factors. Hence, we here analyzed Sox2, a human homolog of a chicken gastric transcription factor, with reference to our new classification for gastric/intestinal (GI)-mixed type IM.
- Publication
Journal of cancer research and clinical oncology, 2004, Vol 130, Issue 3, p135
- ISSN
0171-5216
- Publication type
Journal Article
- DOI
10.1007/s00432-003-0519-6