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- Title
Cortical malformations: a frequent cause of epilepsy in children.
- Authors
Lagae, L
- Abstract
In this review, a simplified scheme for classification of cortical malformations is introduced and illustrated based on the work of Barkovich et al. [8]. Detailed MRI studies identify cortical malformations as a major cause of epilepsy in children. Two aspects that are becoming increasingly important for the paediatrician are emphasised. First, knowledge of the genetic background of cortical malformations is necessary for appropriate genetic counselling. Although the majority of cortical malformations occur sporadically, recent studies have shown a familial pattern in specific epilepsy syndromes associated with cortical malformations. Second, the epilepsy becomes refractory to the common anti-epileptic drugs in many patients with cortical malformations so that epilepsy surgery should be considered. In this respect, the paediatrician can play a pivotal role in referring candidate patients for further specialised assessment.
- Publication
European journal of pediatrics, 2000, Vol 159, Issue 8, p555
- ISSN
0340-6199
- Publication type
Journal Article
- DOI
10.1007/s004310000452