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- Title
Associations between metabolic syndrome components and markers of inflammation in Welsh school children.
- Authors
Thomas, Non Eleri; Rowe, David A; Murtagh, Elaine M; Stephens, Jeffrey W; Williams, Rhys
- Abstract
We investigated the multivariate dimensionality and strength of the relationship between metabolic syndrome (MetS) and inflammation in children. Caucasian school children (N = 229; 12-14 years) from Wales were tested on several health indicators including measures of body composition, inflammation, fasting glucose regulation, blood pressure, and lipids. The multivariate association between MetS and inflammation was investigated via canonical correlation analysis. Data were corrected for non-normality by log transformation, and sex-specific z-scores computed for variables where there was a significant sex difference. Structure r's were interpreted to determine the dimensions of MetS and inflammation responsible for significant canonical variates. The overall multivariate association between MetS and inflammation was significant (Wilks' Lambda = 0.54, p < 0.001). The relationship was explained primarily by the waist circumference dimension of MetS (CC = 0.87) and inflammatory markers of fibrinogen (CC = 0.52) and C-reactive protein (CC = 0.50). The pattern of results was similar regardless of whether variables were adjusted for sex differences.
- Publication
European journal of pediatrics, 2018, Vol 177, Issue 3, p409
- ISSN
1432-1076
- Publication type
Journal Article
- DOI
10.1007/s00431-017-3065-y