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- Title
Combination of vancomycin and rifampicin for the treatment of persistent coagulase-negative staphylococcal bacteremia in preterm neonates.
- Authors
Rodriguez-Guerineau, Luciana; Salvia-Roigés, María Dolors; León-Lozano, Marisol; Rodríguez-Miguélez, José Manuel; Figueras-Aloy, Josep
- Abstract
Coagulase-negative staphylococci are the most common cause of late-onset sepsis in premature neonates. The optimal approach in persistent coagulase-negative staphylococcal bacteremia, despite adequate treatment with glycopeptides, is not well established. A retrospective study was conducted on preterm neonates with persistent coagulase-negative staphylococcal bacteremia treated with the combination of vancomycin-rifampicin. Ten cases were included, with a median gestational age of 26 weeks (range 24 weeks + 3 days-31 weeks + 4 days, interquartile range 25 weeks + 3 days-29 weeks + 3 days) and a median birth weight of 715 g (range 555-2,030). The median age at the onset of infection was 9 days (range 5-37). The most frequent clinical presentation was apnea or increased ventilatory support. Bacteremia persisted for a median of 9 (range 6-19) days until rifampicin initiation. Bacteremia was resolved in all cases on vancomycin-rifampicin with no serious side effects.
- Publication
European journal of pediatrics, 2013, Vol 172, Issue 5, p693
- ISSN
1432-1076
- Publication type
Journal Article
- DOI
10.1007/s00431-012-1927-x