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- Title
Regulation of transient receptor potential (TRP) channels by phosphoinositides.
- Authors
Rohacs, Tibor; Nilius, Bernd
- Abstract
This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP(2)) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP(2) and discusses some future challenges of this fascinating topic.
- Publication
Pflugers Archiv : European journal of physiology, 2007, Vol 455, Issue 1, p157
- ISSN
0031-6768
- Publication type
Journal Article
- DOI
10.1007/s00424-007-0275-6