We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sodium-dependent ascorbic acid transporter family SLC23.
- Authors
Takanaga, Hitomi; Mackenzie, Bryan; Hediger, Matthias A
- Abstract
l-Ascorbic acid (vitamin C) is an effective antioxidant and an essential cofactor in numerous enzymatic reactions. Two Na(+)-dependent vitamin C transporters (SVCT1 and SVCT2) are members of the SLC23 human gene family, which also contains two orphan members. SVCT1 and SVCT2 display similar properties, including high affinity for l-ascorbic acid, but are discretely distributed. SVCT1 is confined to epithelial systems including intestine, kidney, and liver, whereas SVCT2 serves a host of metabolically active and specialized cells and tissues including neurons, the eye, lung, and placenta, and a range of neuroendocrine, exocrine, and endothelial tissues. An SVCT2-knockout mouse reveals an obligatory requirement for SVCT2, but many of the specific roles of this transporter remain unclear.
- Publication
Pflugers Archiv : European journal of physiology, 2004, Vol 447, Issue 5, p677
- ISSN
0031-6768
- Publication type
Journal Article
- DOI
10.1007/s00424-003-1104-1