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- Title
The sodium/calcium exchanger family-SLC8.
- Authors
Quednau, Beate D; Nicoll, Debora A; Philipson, Kenneth D
- Abstract
The Na(+)/Ca(2+) exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca(2+) efflux and thus contribute to intracellular Ca(2+) homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na(+) for 1 intracellular Ca(2+). In addition to transporting Na(+) and Ca(2+), NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.
- Publication
Pflugers Archiv : European journal of physiology, 2004, Vol 447, Issue 5, p543
- ISSN
0031-6768
- Publication type
Journal Article
- DOI
10.1007/s00424-003-1065-4