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- Title
Subsequent gene expression pattern in dendritic cells following multiple trauma.
- Authors
Geiger, Emanuel V; Maier, Marcus; Schiessling, Serin; Wutzler, Sebastian; Lehnert, Mark; Marzi, Ingo; Henrich, Dirk
- Abstract
Major trauma initiates a systemic inflammatory response, which is characterized by systemic release of various chemokines. There is growing evidence for the extraordinary role of dendritic cells (DC) as professional antigen-presenting cells and activators of the immune response. Recently, the impact of severe trauma on DC transcriptomic activation was demonstrated. The purpose of the present study was to evaluate gene expression pattern in DC following multiple trauma to gain further understanding of the mechanisms of posttraumatic immune response.
- Publication
Langenbeck's archives of surgery, 2013, Vol 398, Issue 2, p327
- ISSN
1435-2451
- Publication type
Journal Article
- DOI
10.1007/s00423-012-1031-8