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- Title
Effect of age and exercise training on protein:protein interactions among eNOS and its regulatory proteins in rat aortas.
- Authors
Luttrell, Meredith J; Seawright, John W; Wilson, Emily; Woodman, Christopher R
- Abstract
We tested the hypothesis that impaired endothelium-dependent relaxation in aged aorta is due, in part, to altered protein:protein interactions between endothelial nitric oxide synthase (eNOS) and key regulatory proteins resulting in impaired nitric oxide (NO)-mediated relaxation. We also hypothesized that endurance exercise training improves or restores NO-mediated vasorelaxation in aged aorta by reversing the detrimental effects of aging on protein:protein interaction between eNOS and its key regulatory proteins.
- Publication
European journal of applied physiology, 2013, Vol 113, Issue 11, p2761
- ISSN
1439-6327
- Publication type
Journal Article
- DOI
10.1007/s00421-013-2715-7