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- Title
A potential therapeutic strategy for inhibition of ocular neovascularization with a new endogenous protein: rhEDI-8t.
- Authors
Zhang, Ling; Shen, Xi; Lu, Qing; Zhou, Qingwei; Gu, Jiaqi; Gan, Renbao; Zhang, Hui; Sun, Xiaodong; Xie, Bing
- Abstract
Endogenous angiogenesis inhibitors act as natural negative feedback in the focal area during the neovascularization process, and have less interference on physiological angiogenesis, and thus fewer negative side-effects. These inhibitors are potential candidates to combine with or substitutes for current popular anti-angiogenesis treatments to have synergistic effect. In this study, the effects of recombinant endothelial growth inhibitor protein (rhEDI-8t), a novel endogenous protein originated from collagen VIII, was investigated on ocular neovascularization (NV). Endostatin, a well-identified endogenous angiogenesis inhibitor, was compared in parallel and served as a positive control.
- Publication
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012, Vol 250, Issue 5, p731
- ISSN
1435-702X
- Publication type
Journal Article
- DOI
10.1007/s00417-011-1765-y