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- Title
Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.
- Authors
Bhamra, Gurpreet S; Hausenloy, Derek J; Davidson, Sean M; Carr, Richard D; Paiva, Marta; Wynne, Abigail M; Mocanu, Mihaela M; Yellon, Derek M
- Abstract
In the majority of studies, metformin has been demonstrated to cardioprotect diabetic patients, the mechanism of which is unclear. We hypothesized that metformin cardioprotects the ischemic heart through the Akt-mediated inhibition of mitochondrial permeability transition pore (mPTP) opening.
- Publication
Basic research in cardiology, 2008, Vol 103, Issue 3, p274
- ISSN
0300-8428
- Publication type
Journal Article
- DOI
10.1007/s00395-007-0691-y