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- Title
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism.
- Authors
Campbell, Yan; Fantacone, Mary L; Gombart, Adrian F
- Abstract
Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense, and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs bind lipopolysaccharides, act as chemoattractants for immune cells and bind to cellular receptors and modulate the expression of cytokines and chemokines. These additional biological activities may explain the role of AMPs in inflammatory diseases and cancer. Modulating the endogenous expression of AMPs offers potential therapeutic treatments for infection and disease.
- Publication
European journal of nutrition, 2012, Vol 51, Issue 8, p899
- ISSN
1436-6215
- Publication type
Journal Article
- DOI
10.1007/s00394-012-0415-4