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- Title
E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression.
- Authors
Jungck, M; Grünhage, F; Spengler, U; Dernac, A; Mathiak, M; Caspari, R; Friedl, W; Sauerbruch, T
- Abstract
The adenomatous polyposis coli (APC) protein plays a crucial role in the regulation of beta-catenin, which is linked to the cell adhesion molecule E-cadherin. Furthermore, beta-catenin and cyclooxygenase-2 (COX-2) are both involved in the activation of nuclear transcription factors inducing cell proliferation. Germline mutations in the APC gene are the cause of familial adenomatous polyposis (FAP). To characterise the expression pattern of these proteins in FAP in comparison with sporadic adenomas, we studied 18 FAP-associated adenomas, 16 sporadic adenomas and seven normal colonic controls.
- Publication
International journal of colorectal disease, 2004, Vol 19, Issue 5, p438
- ISSN
0179-1958
- Publication type
Journal Article
- DOI
10.1007/s00384-003-0575-z