We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Crohn's disease: in defense of a microvascular aetiology.
- Authors
Thornton, Michelle; Solomon, Michael J
- Abstract
There appears little doubt that microvascular ischaemia is involved in Crohn's disease. Studies have consistently demonstrated that the number of blood vessels and the total volume of blood feeding segments of bowel with Crohn's disease are reduced. However, the aetiology of the microvascular ischaemia is yet to be determined. Potential aetiological factors that appear to be disease specific include increased mesenteric platelet aggregation and increased platelet surface expression of P-selectin and GP53. However, there are several other factors known to be raised in active and quiescent disease for which disease specificity is not yet known, including increased submucosal endothelial endothelin-1 receptor expression, increased m RNA expression for several interleukins and cytokines including TNFalpha, increased PAF and thrombomodulin and finally altered cellular adhesion molecule expression.
- Publication
International journal of colorectal disease, 2002, Vol 17, Issue 5, p287
- ISSN
0179-1958
- Publication type
Journal Article
- DOI
10.1007/s00384-002-0408-5