Works matching AU Bock, Christoph

Results: 133

DNA methylation: a matter of culture.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 3, p. 249, doi. 10.1038/nsmb.2531

By:

Bock, Christoph;
Wutz, Anton

Publication type:

Article

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.

Published in:

Hippocampus, 2014, v. 24, n. 4, p. 363, doi. 10.1002/hipo.22245

By:

Sanchez‐Mut, Jose Vicente;
Aso, Ester;
Heyn, Holger;
Matsuda, Tadashi;
Bock, Christoph;
Ferrer, Isidre;
Esteller, Manel

Publication type:

Article

DeepBlueR: large-scale epigenomic analysis in R.

Published in:

Bioinformatics, 2017, v. 33, n. 13, p. 2063, doi. 10.1093/bioinformatics/btx099

By:

Albrecht, Felipe;
List, Markus;
Bock, Christoph;
Lengauer, Thomas

Publication type:

Article

LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor.

Published in:

Bioinformatics, 2016, v. 32, n. 4, p. 587, doi. 10.1093/bioinformatics/btv612

By:

Sheffield, Nathan C.;
Bock, Christoph

Publication type:

Article

RRBSMAP: a fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing.

Published in:

Bioinformatics, 2012, v. 28, n. 3, p. 430, doi. 10.1093/bioinformatics/btr668

By:

Xi, Yuanxin;
Bock, Christoph;
Müller, Fabian;
Sun, Deqiang;
Meissner, Alexander;
Li, Wei

Publication type:

Article

Computational epigenetics.

Published in:

Bioinformatics, 2008, v. 24, n. 1, p. 1, doi. 10.1093/bioinformatics/btm546

By:

Christoph Bock;
Thomas Lengauer

Publication type:

Article

BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing.

Published in:

Bioinformatics, 2005, v. 21, n. 21, p. 4067, doi. 10.1093/bioinformatics/bti652

By:

Christoph Bock;
Sabine Reither;
Thomas Mikeska;
Martina Paulsen;
Jörn Walter;
Thomas Lengauer

Publication type:

Article

Analysis and Prediction of Helix Shift Errors in Homology Modeling.

Published in:

In Silico Biology, 2006, v. 6, n. 1/2, p. 131, doi. 10.3233/isb-00228

By:

Bock, Christoph;
Hesser, Jürgen

Publication type:

Article

Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33841-w

By:

Bock, Christoph;
Löhr, Frank;
Tumulka, Franz;
Reichel, Katrin;
Würz, Julia;
Hummer, Gerhard;
Schäfer, Lars;
Tampé, Robert;
Joseph, Benesh;
Bernhard, Frank;
Dötsch, Volker;
Abele, Rupert

Publication type:

Article

Buffy coat signatures of breast cancer risk in a prospective cohort study.

Published in:

Clinical Epigenetics, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13148-023-01509-6

By:

Chung, Felicia Fei-Lei;
Maldonado, Sandra González;
Nemc, Amelie;
Bouaoun, Liacine;
Cahais, Vincent;
Cuenin, Cyrille;
Salle, Aurelie;
Johnson, Theron;
Ergüner, Bekir;
Laplana, Marina;
Datlinger, Paul;
Jeschke, Jana;
Weiderpass, Elisabete;
Kristensen, Vessela;
Delaloge, Suzette;
Fuks, François;
Risch, Angela;
Ghantous, Akram;
Plass, Christoph;
Bock, Christoph

Publication type:

Article

Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data.

Published in:

Genome Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s13059-020-02100-5

By:

Fortelny, Nikolaus;
Bock, Christoph

Publication type:

Article

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets.

Published in:

Genome Biology, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s13059-020-02006-2

By:

Marquina-Sanchez, Brenda;
Fortelny, Nikolaus;
Farlik, Matthias;
Vieira, Andhira;
Collombat, Patrick;
Bock, Christoph;
Kubicek, Stefan

Publication type:

Article

Toward understanding and exploiting tumor heterogeneity.

Published in:

Nature Medicine, 2015, v. 21, n. 8, p. 846, doi. 10.1038/nm.3915

By:

Alizadeh, Ash A;
Aranda, Victoria;
Bardelli, Alberto;
Blanpain, Cedric;
Bock, Christoph;
Borowski, Christine;
Caldas, Carlos;
Califano, Andrea;
Doherty, Michael;
Elsner, Markus;
Esteller, Manel;
Fitzgerald, Rebecca;
Korbel, Jan O;
Lichter, Peter;
Mason, Christopher E;
Navin, Nicholas;
Pe'er, Dana;
Polyak, Kornelia;
Roberts, Charles W M;
Siu, Lillian

Publication type:

Article

EMPFEHLUNGEN FÜR DIE UMSETZUNG VON OPEN ACCESS IN ÖSTERREICH.

Published in:

Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen & Bibliothekare, 2015, v. 68, n. 3/4, p. 580

By:

Bauer, Bruno;
Blechl, Guido;
Bock, Christoph;
Danowski, Patrick;
Ferus, Andreas;
Graschopf, Anton;
König, Thomas;
Mayer, Katja;
Reckling, Falk;
Rieck, Katharina;
Seitz, Peter;
Stöger, Herwig;
Welzig, Elvira

Publication type:

Article

Dnmt3a is essential for hematopoietic stem cell differentiation.

Published in:

Nature Genetics, 2012, v. 44, n. 1, p. 23, doi. 10.1038/ng.1009

By:

Challen, Grant A;
Sun, Deqiang;
Jeong, Mira;
Luo, Min;
Jelinek, Jaroslav;
Berg, Jonathan S;
Bock, Christoph;
Vasanthakumar, Aparna;
Gu, Hongcang;
Xi, Yuanxin;
Liang, Shoudan;
Lu, Yue;
Darlington, Gretchen J;
Meissner, Alexander;
Issa, Jean-Pierre J;
Godley, Lucy A;
Li, Wei;
Goodell, Margaret A

Publication type:

Article

Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region.

Published in:

BMC Genomics, 2008, v. 9, p. 1, doi. 10.1186/1471-2164-9-346

By:

Kircher, Martin;
Bock, Christoph;
Paulsen, Martina

Publication type:

Article

Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target <i>CBL, MLL, DDB1</i> and <i>LMO2</i>.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077819

By:

Klampfl, Thorsten;
Milosevic, Jelena D.;
Puda, Ana;
Schönegger, Andreas;
Bagienski, Klaudia;
Berg, Tiina;
Harutyunyan, Ashot S.;
Gisslinger, Bettina;
Rumi, Elisa;
Malcovati, Luca;
Pietra, Daniela;
Elena, Chiara;
Della Porta, Matteo Giovanni;
Pieri, Lisa;
Guglielmelli, Paola;
Bock, Christoph;
Doubek, Michael;
Dvorakova, Dana;
Suvajdzic, Nada;
Tomin, Dragica

Publication type:

Article

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05625-9

By:

Karjalainen, Anzhelika;
Witalisz-Siepracka, Agnieszka;
Prchal-Murphy, Michaela;
Martin, David;
Sternberg, Felix;
Krunic, Milica;
Dolezal, Marlies;
Fortelny, Nikolaus;
Farlik, Matthias;
Macho-Maschler, Sabine;
Lassnig, Caroline;
Meissl, Katrin;
Amenitsch, Lena;
Lederer, Therese;
Pohl, Elena;
Gotthardt, Dagmar;
Bock, Christoph;
Decker, Thomas;
Strobl, Birgit;
Müller, Mathias

Publication type:

Article

Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets.

Published in:

EMBO Journal, 2022, v. 41, n. 17, p. 1, doi. 10.15252/embj.2022111118

By:

Vértesy, Ábel;
Eichmüller, Oliver L;
Naas, Julia;
Novatchkova, Maria;
Esk, Christopher;
Balmaña, Meritxell;
Ladstaetter, Sabrina;
Bock, Christoph;
von Haeseler, Arndt;
Knoblich, Juergen A

Publication type:

Article

Life‐long impairment of glucose homeostasis upon prenatal exposure to psychostimulants.

Published in:

EMBO Journal, 2020, v. 39, n. 1, p. N.PAG, doi. 10.15252/embj.2018100882

By:

Korchynska, Solomiia;
Krassnitzer, Maria;
Malenczyk, Katarzyna;
Prasad, Rashmi B;
Tretiakov, Evgenii O;
Rehman, Sabah;
Cinquina, Valentina;
Gernedl, Victoria;
Farlik, Matthias;
Petersen, Julian;
Hannes, Sophia;
Schachenhofer, Julia;
Reisinger, Sonali N;
Zambon, Alice;
Asplund, Olof;
Artner, Isabella;
Keimpema, Erik;
Lubec, Gert;
Mulder, Jan;
Bock, Christoph

Publication type:

Article

Defining the impact of adjuvant treatment on the prognosis of patients with inoperable glioblastoma undergoing biopsy only: does the survival benefit outweigh the treatment effort?

Published in:

Neurosurgical Review, 2022, v. 45, n. 3, p. 2339, doi. 10.1007/s10143-022-01754-y

By:

Löber-Handwerker, Ronja;
Döring, Katja;
Bock, Christoph;
Rohde, Veit;
Malinova, Vesna

Publication type:

Article

First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience.

Published in:

Neurosurgical Review, 2010, v. 33, n. 4, p. 441, doi. 10.1007/s10143-010-0280-7

By:

Bock, Hans Christoph;
Puchner, Maximilian Josef Anton;
Lohmann, Frauke;
Schütze, Michael;
Koll, Simone;
Ketter, Ralf;
Buchalla, Ruediger;
Rainov, Nikolai;
Kantelhardt, Sven R.;
Rohde, Veit;
Giese, Alf

Publication type:

Article

An extended combinatorial N, C, and $$ ^{13} {\text{C}}^{\prime } $$ labeling approach to protein backbone resonance assignment.

Published in:

Journal of Biomolecular NMR, 2015, v. 62, n. 3, p. 263, doi. 10.1007/s10858-015-9941-8

By:

Löhr, Frank;
Tumulka, Franz;
Bock, Christoph;
Abele, Rupert;
Dötsch, Volker

Publication type:

Article

Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.

Published in:

Journal of Biomolecular NMR, 2013, v. 57, n. 2, p. 141, doi. 10.1007/s10858-013-9774-2

By:

Tumulka, Franz;
Roos, Christian;
Löhr, Frank;
Bock, Christoph;
Bernhard, Frank;
Dötsch, Volker;
Abele, Rupert

Publication type:

Article

Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: a feasibility study.

Published in:

2011

By:

Xyda A;
Haberland U;
Klotz E;
Bock HC;
Jung K;
Knauth M;
Schramm R;
Psychogios MN;
Erb G;
Schramm P;
Xyda, Argyro;
Haberland, Ulrike;
Klotz, Ernst;
Bock, Hans Christoph;
Jung, Klaus;
Knauth, Michael;
Schramm, Ramona;
Psychogios, Marios Nikos;
Erb, Gunter;
Schramm, Peter

Publication type:

journal article

Paediatric pineal region cysts: enigma or impaired neurofluid system?

Published in:

Child's Nervous System, 2023, v. 39, n. 12, p. 3457, doi. 10.1007/s00381-023-06000-4

By:

Ludwig, Hans C.;
Dreha-Kulaczewski, Steffi;
Bock, Hans Christoph

Publication type:

Article

Protocol for the multicentre prospective paediatric craniectomy and cranioplasty registry (pedCCR) under the auspices of the European Society for Paediatric Neurosurgery (ESPN).

Published in:

Child's Nervous System, 2022, v. 38, n. 8, p. 1461, doi. 10.1007/s00381-022-05540-5

By:

Beez, Thomas;
Schuhmann, Martin U.;
Frassanito, Paolo;
Di Rocco, Federico;
Thomale, Ulrich W.;
Bock, Hans Christoph

Publication type:

Article

An adjustable gravitational valve for initial VP-shunt treatment in hydrocephalic preterm neonates and infants below 1 year of age.

Published in:

Child's Nervous System, 2021, v. 37, n. 11, p. 3497, doi. 10.1007/s00381-021-05250-4

By:

Bock, Hans Christoph;
von Philipp, Gottberg;
Ludwig, Hans Christoph

Publication type:

Article

TROPHY registry study design: a prospective, international multicenter study for the surgical treatment of posthemorrhagic hydrocephalus in neonates.

Published in:

Child's Nervous System, 2019, v. 35, n. 4, p. 613, doi. 10.1007/s00381-019-04077-4

By:

Thomale, Ulrich-Wilhelm;
Al-Hakim, Sara;
Schaumann, Andreas;
Cinalli, Giuseppe;
Kulkarni, Abhaya V.;
Roth, Jonathan;
Constantini, Shlomi;
Bührer, Christoph;
Cavalheiro, Sergio;
Sgouros, Spyros;
Bock, Hans Christoph

Publication type:

Article

Implementing a digital real-time Hydrocephalus and Shunt Registry to evaluate contemporary pattern of care and surgical outcome in pediatric hydrocephalus.

Published in:

Child's Nervous System, 2018, v. 34, n. 3, p. 457, doi. 10.1007/s00381-017-3654-0

By:

Kanzler, Maximilian;
Ludwig, Hans Christoph;
Bock, Hans Christoph;
Thomale, Ulrich-Wilhelm

Publication type:

Article

Endoscope-enhanced fluorescence-guided microsurgery increases survival in patients with glioblastoma.

Published in:

Acta Neurochirurgica, 2023, v. 165, n. 12, p. 4221, doi. 10.1007/s00701-023-05862-6

By:

Bettag, Christoph;
Schatlo, Bawarjan;
Abboud, Tammam;
Behme, Daniel;
Bock, Christoph;
von der Brelie, Christian;
Rohde, Veit;
Mielke, Dorothee

Publication type:

Article

DNA methylation QTL analysis identifies new regulators of human longevity.

Published in:

Human Molecular Genetics, 2020, v. 29, n. 7, p. 1154, doi. 10.1093/hmg/ddaa033

By:

Szymczak, Silke;
Dose, Janina;
Torres, Guillermo G.;
Heinsen, Femke-Anouska;
Venkatesh, Geetha;
Datlinger, Paul;
Nygaard, Marianne;
Mengel-From, Jonas;
Flachsbart, Friederike;
Klapper, Wolfram;
Christensen, Kaare;
Lieb, Wolfgang;
Schreiber, Stefan;
Häsler, Robert;
Bock, Christoph;
Franke, Andre;
Nebel, Almut

Publication type:

Article

Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39210-0

By:

Fetahu, Irfete S.;
Esser-Skala, Wolfgang;
Dnyansagar, Rohit;
Sindelar, Samuel;
Rifatbegovic, Fikret;
Bileck, Andrea;
Skos, Lukas;
Bozsaky, Eva;
Lazic, Daria;
Shaw, Lisa;
Tötzl, Marcus;
Tarlungeanu, Dora;
Bernkopf, Marie;
Rados, Magdalena;
Weninger, Wolfgang;
Tomazou, Eleni M.;
Bock, Christoph;
Gerner, Christopher;
Ladenstein, Ruth;
Farlik, Matthias

Publication type:

Article

Response to comment on "Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2".

Published in:

Science Translational Medicine, 2021, v. 13, n. 617, p. 1, doi. 10.1126/scitranslmed.abj3222

By:

Nicholson, Michael D.;
Endler, Lukas;
Popa, Alexandra;
Genger, Jakob-Wendelin;
Bock, Christoph;
Michor, Franziska;
Bergthaler, Andreas

Publication type:

Article

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease.

Published in:

Science Translational Medicine, 2020, v. 12, n. 570, p. 1, doi. 10.1126/scitranslmed.abb7028

By:

Strobl, Johanna;
Pandey, Ram Vinay;
Krausgruber, Thomas;
Bayer, Nadine;
Kleissl, Lisa;
Reininger, Bärbel;
Vieyra-Garcia, Pablo;
Wolf, Peter;
Jentus, Maaia-Margo;
Mitterbauer, Margit;
Wohlfarth, Philipp;
Rabitsch, Werner;
Stingl, Georg;
Bock, Christoph;
Stary, Georg

Publication type:

Article

Parallel reverse genetic screening in mutant human cells using transcriptomics.

Published in:

Molecular Systems Biology, 2016, v. 12, n. 8, p. n/a, doi. 10.15252/msb.20166890

By:

Gapp, Bianca V;
Konopka, Tomasz;
Penz, Thomas;
Dalal, Vineet;
Bürckstümmer, Tilmann;
Bock, Christoph;
Nijman, Sebastian MB

Publication type:

Article

CpG Island Mapping by Epigenome Prediction.

Published in:

PLoS Computational Biology, 2007, v. 3, n. 6, p. e110, doi. 10.1371/journal.pcbi.0030110

By:

Bock, Christoph;
Walter, Jörn;
Paulsen, Martina;
Lengauer, Thomas

Publication type:

Article

The Human Genomic Melting Map.

Published in:

PLoS Computational Biology, 2007, v. 3, n. 5, p. e93, doi. 10.1371/journal.pcbi.0030093

By:

Fang Liu;
Tøstesen, Eivind;
Sundet, Jostein K.;
Jenssen, Tor-Kristian;
Bock, Christoph;
Jerstad, Geir Ivar;
Thilly, William G.;
Hovig, Eivind

Publication type:

Article

On rational homotopy and minimal models.

Published in:

Forum Mathematicum, 2021, v. 33, n. 1, p. 283, doi. 10.1515/forum-2020-0123

By:

Bock, Christoph

Publication type:

Article

Geography of non-formal symplectic and contact manifolds.

Published in:

Forum Mathematicum, 2011, v. 23, n. 4, p. 713, doi. 10.1515/FORM.2011.025

By:

Bock, Christoph

Publication type:

Article

Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece: a case collection study.

Published in:

Acta Neurochirurgica, 2011, v. 153, n. 3, p. 533, doi. 10.1007/s00701-010-0923-z

By:

Bock, Hans Christoph;
Cohnen, Joseph;
Keric, Naureen;
Kantelhardt, Sven Rainer;
Giese, Alf

Publication type:

Article

Intra-osseous ultrasound for pedicle screw positioning in the subaxial cervical spine: an experimental study.

Published in:

Acta Neurochirurgica, 2010, v. 152, n. 4, p. 655, doi. 10.1007/s00701-009-0447-6

By:

Kantelhardt, Sven Rainer;
Bock, Hans Christoph;
Siam, Laila;
Larsen, Jörg;
Burger, Ralf;
Schillinger, Wolfgang;
Bockermann, Volker;
Rohde, Veit;
Giese, Alf

Publication type:

Article

Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK--driven lymphomagenesis.

Published in:

Life Science Alliance, 2021, v. 4, n. 2, p. 1, doi. 10.26508/lsa.202000794

By:

Redl, Elisa;
Sheibani-Tezerji, Raheleh;
de Jesus Cardona, Crhistian;
Hamminger, Patricia;
Timelthaler, Gerald;
Hassler, Melanie Rosalia;
Zrimšek, Maša;
Lagger, Sabine;
Dillinger, Thomas;
Hofbauer, Lorena;
Draganić, Kristina;
Tiefenbacher, Andreas;
Kothmayer, Michael;
Dietz, Charles H.;
Ramsahoye, Bernard H.;
Kenner, Lukas;
Bock, Christoph;
Seiser, Christian;
Ellmeier, Wilfried;
Schweikert, Gabriele

Publication type:

Article

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

Published in:

Scientific Reports, 2015, p. 17341, doi. 10.1038/srep17341

By:

Blees, Andreas;
Reichel, Katrin;
Trowitzsch, Simon;
Fisette, Olivier;
Bock, Christoph;
Abele, Rupert;
Hummer, Gerhard;
Schäfer, Lars V.;
Tampé, Robert

Publication type:

Article

Quantitative comparison of genome-wide DNA methylation mapping technologies.

Published in:

Nature Biotechnology, 2010, v. 28, n. 10, p. 1106, doi. 10.1038/nbt.1681

By:

Bock, Christoph;
Tomazou, Eleni M.;
Brinkman, Arie B.;
Müller, Fabian;
Simmer, Femke;
Hongcang Gu;
Jäger, Natalie;
Gnirke, Andreas;
Stunnenberg, Hendrik G.;
Meissner, Alexander

Publication type:

Article

Implantation of Carmustine wafers after resection of malignant glioma with and without opening of the ventricular system.

Published in:

Journal of Neuro-Oncology, 2021, v. 153, n. 3, p. 519, doi. 10.1007/s11060-021-03792-w

By:

Bettag, Christoph;
Hussein, Abdelhalim;
Sachkova, Alexandra;
Bock, Hans Christoph;
Mielke, Dorothee;
Rohde, Veit;
Abboud, Tammam

Publication type:

Article

Acknowledging and citing core facilities: Key contributions to data lifecycle should be recognised in the scientific literature.

Published in:

EMBO Reports, 2022, v. 23, n. 9, p. 1, doi. 10.15252/embr.202255734

By:

Kivinen, Katja;
van Luenen, Henri G A M;
Alcalay, Myriam;
Bock, Christoph;
Dodzian, Joanna;
Hoskova, Katerina;
Hoyle, Danielle;
Hradil, Ondrej;
Christensen, Sofie Kjellerup;
Korn, Bernhard;
Kosteas, Theodoros;
Morales, Mònica;
Skowronek, Krzysztof;
Theodorou, Vasiliki;
Van Minnebruggen, Geert;
Salamero, Jean;
Premvardhan, Lavanya

Publication type:

Article

Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.

Published in:

EMBO Reports, 2016, v. 17, n. 2, p. 178, doi. 10.15252/embr.201540946

By:

Li, Jin;
Klughammer, Johanna;
Farlik, Matthias;
Penz, Thomas;
Spittler, Andreas;
Barbieux, Charlotte;
Berishvili, Ekaterine;
Bock, Christoph;
Kubicek, Stefan

Publication type:

Article

LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data.

Published in:

Bioinformatics Advances, 2022, v. 2, n. 1, p. 1, doi. 10.1093/bioadv/vbac017

By:

Peneder, Peter;
Bock, Christoph;
Tomazou, Eleni M

Publication type:

Article

Analysing and interpreting DNA methylation data.

Published in:

2012

By:

Bock C;
Bock, Christoph

Publication type:

journal article