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- Title
Gene expression profiling in human craniosynostoses: a tool to investigate the molecular basis of suture ossification.
- Authors
Bernardini, Camilla; Barba, Marta; Tamburrini, Gianpiero; Massimi, Luca; Di Rocco, Concezio; Michetti, Fabrizio; Lattanzi, Wanda
- Abstract
Non-syndromic craniosynostoses (NSC) occur as isolated skull malformations due to the premature ossification of one (single-suture forms) or more (complex forms) calvarial sutures and represent the most frequent form of craniosynostosis worldwide. The etiology of NSC is still largely unknown as a genetic basis can be rarely demonstrated especially in single-suture forms. In these cases, during the prenatal/perinatal development of affected patients, only one suture undergoes a premature direct ossification within an otherwise physiologically grown skull. This could suggest that definite somatic alterations, possibly due to unclear environmental agents, occur locally at the site of premature suture fusion during skull development. A promising tool to investigate the molecular mechanisms that may orchestrate this event is the comparative analysis of suture- and synostosis-derived tissues and cells.
- Publication
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012, Vol 28, Issue 9, p1295
- ISSN
1433-0350
- Publication type
Journal Article
- DOI
10.1007/s00381-012-1780-2