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- Title
The management of subependymal giant cell tumors in tuberous sclerosis: a clinician's perspective.
- Authors
Moavero, Romina; Pinci, Mariangela; Bombardieri, Roberta; Curatolo, Paolo
- Abstract
Tuberous sclerosis (TSC) is a genetic multisystem disorder associated with hamartomas in several organs including subependymal giant cell tumors (SGCT). SGCT have the potential to grow and therefore to become symptomatic and are one of the main causes of death in TSC individuals. Surgical resection is the procedure of choice for SGCT. However, the discovery of mTOR pathway upregulation in TSC-associated tumors and recent evidence that mTOR inhibitors may induce regression of SGCT open up new treatment strategies. Based on a review of the currently available literature and on personal experience, current options for the management of TSC patients and appropriate indications, taking into account benefits and risks of surgery and pharmacotherapy, are discussed.
- Publication
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011, Vol 27, Issue 8, p1203
- ISSN
1433-0350
- Publication type
Journal Article
- DOI
10.1007/s00381-011-1406-0