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- Title
Carboplatin and ototoxicity: hearing loss rates among survivors of childhood medulloblastoma.
- Authors
Musial-Bright, Lindy; Fengler, Rüdiger; Henze, Günter; Hernáiz Driever, Pablo
- Abstract
Patients with medulloblastoma are exposed to ototoxic treatments including radiation therapy and platinum chemotherapy. The favorable toxicity profile of carboplatin led us to substitute this chemotherapeutic agent for cisplatin in the HIT-1991, HIT-MED-1999, and HIT-2000 chemotherapy protocols. We retrospectively investigated its consequences in terms of overall survival and ototoxicity rates.
- Publication
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011, Vol 27, Issue 3, p407
- ISSN
1433-0350
- Publication type
Journal Article
- DOI
10.1007/s00381-010-1300-1