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- Title
IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group.
- Authors
Pollack, Ian F; Hamilton, Ronald L; Sobol, Robert W; Nikiforova, Marina N; Lyons-Weiler, Maureen A; LaFramboise, William A; Burger, Peter C; Brat, Daniel J; Rosenblum, Marc K; Holmes, Emiko J; Zhou, Tianni; Jakacki, Regina I; Children's Oncology Group
- Abstract
Recent studies have demonstrated a high frequency of IDH mutations in adult "secondary" malignant gliomas arising from preexisting lower grade lesions, often in young adults, but not in "primary" gliomas. Because pediatric malignant gliomas share some molecular features with adult secondary gliomas, we questioned whether a subset of these tumors also exhibited IDH mutations.
- Publication
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011, Vol 27, Issue 1, p87
- ISSN
1433-0350
- Publication type
Journal Article
- DOI
10.1007/s00381-010-1264-1