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- Title
Treatment of cystic craniopharyngioma with phosphorus-32 intracavitary irradiation.
- Authors
Rong Zhao; Jinglan Deng; Xiaoyan Liang; Jin Zeng; Xiaoyuan Chen; Jing Wang
- Abstract
The aim of the study was to evaluate the effect of phosphorus-32 colloid ([32P]) intracavitary irradiation on the treatment of patients with cystic craniopharyngiomas. Twenty patients with predominantly cystic craniopharyngiomas were admitted from 1981 to 2006. Eleven patients had [32P] intracavitary irradiation by stereotactic injection or Ommaya cyst instillation as the primary treatment, and the remaining nine had the same internal irradiation as an adjuvant treatment after tumor resection. A calculated irradiation dose of 400~500 Gy per once was delivered to the cyst wall. The patients were followed up ranging from 36 to 336 months; no operative morbidity or mortality was found from [32P] intracavitary irradiation. Fourteen patients (70%) had tumor progression and required further two to four times intracavitary irradiation. All 20 cases achieved tumor shrinkage or stabilization with effective outcome 3–6 months after the last [32P] therapy. For patients with cystic craniopharyngioma, [32P] administration by stereotactic injection or Ommaya cyst instillation is a safe and helpful option, which could improve the life quality, prolong the life span, and enhance the survival rate of cystic craniopharyngioma patients.
- Publication
Child's Nervous System, 2010, Vol 26, Issue 5, p669
- ISSN
0256-7040
- Publication type
Academic Journal
- DOI
10.1007/s00381-009-1025-1