Works matching DE "TUMOR microenvironment"

Results: 5000

Necroptosis in cancer: insight from epigenetic, post-transcriptional and post-translational modifications.

Published in:

Journal of Hematology & Oncology, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13045-025-01726-x

By:

Tang, Jinxin;
Zhuang, Yan;
Zhang, Yibo;
Hu, Hongkun;
Wang, Hua;
Xu, Haodong;
Li, Yintao;
Tu, Chao

Publication type:

Article

Sonodynamic biomimetic-nanomedicine fight cancers.

Published in:

Journal of Nanobiotechnology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12951-025-03583-9

By:

Zhang, Anni;
Zheng, Xu;
Yan, Guangqi;
Liu, Xiaoqi;
Xie, DongXuan;
Xu, Xiaohe;
Sun, Mengchi;
Liu, Zhijun

Publication type:

Article

The 10 commandments of immunoregulation in lymphoma.

Published in:

Science Immunology, 2025, v. 10, n. 109, p. N.PAG, doi. 10.1126/sciimmunol.aea0950

By:

de los Reyes Capilla Guerra, Maria;
Griffin, Gabriel K.

Publication type:

Article

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors.

Published in:

Science Immunology, 2025, v. 10, n. 109, p. 1, doi. 10.1126/sciimmunol.adt3537

By:

Ray, Arja;
Bassette, Molly;
Hu, Kenneth H.;
Pass, Lomax F.;
Courau, Tristan;
Samad, Bushra;
Combes, Alexis J.;
Johri, Vrinda;
Davidson, Brittany;
Wai, Katherine;
Ha, Patrick;
Hernandez, Grace;
Zaleta-Linares, Itzia;
Krummel, Matthew F.

Publication type:

Article

Noncanonical Hedgehog signaling through Smoothened controls cytotoxic T cell migration in the tumor microenvironment.

Published in:

Science Immunology, 2025, v. 10, n. 109, p. 1, doi. 10.1126/sciimmunol.adr3127

By:

Kapeni, Chrysa;
O'Brien, Louise;
Sabirova, Dilyara;
Cast, Oliver;
Carbonaro, Valentina;
Clark-Leonard, Stephen;
Machel, Anne C.;
Beke, Flavio;
McDonald, Sarah;
Fife, Kate;
de la Roche, Maike

Publication type:

Article

A lipid metabolism-related gene signature predicts prognosis after tamoxifen treatment in ER + breast cancer and reflects tumor microenvironment heterogeneity through single-cell analysis.

Published in:

BMC Medical Genomics, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s12920-025-02194-5

By:

Ma, Linxiaoxi;
Qian, Bei;
Peng, Chen;
Liu, Gang;
Shen, Hao

Publication type:

Article

Construction of an immune prediction model for osteosarcoma based on coagulation-related genes.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03214-7

By:

Jiang, Ye;
Yuan, Huiqi;
Cao, Yongping

Publication type:

Article

Biomimetic nanoparticles delivered hedgehog pathway inhibitor to modify tumour microenvironment and improved chemotherapy for pancreatic carcinoma.

Published in:

Artificial Cells, Nanomedicine & Biotechnology, 2018, v. 46, p. 1088, doi. 10.1080/21691401.2018.1445093

By:

Jiang, Ting;
Zhang, Bo;
Zhang, Long;
Wu, Xuemei;
Li, Haichun;
Shen, Shun;
Luo, Zimiao;
Liu, Xianping;
Hu, Yu;
Pang, Zhiqing;
Jiang, Xinguo

Publication type:

Article

RNA sequencing and immunohistochemistry jointly improve tumor biomarker interpretation.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-12780-3

By:

Kushnarev, Vladimir;
Stupichev, Danil;
Davitavyan, Suren;
Kriukov, Kirill;
Shanthappa, Basavaraja U.;
Butusova, Anna;
Menshikova, Sofia;
Belozerova, Anna;
Shvyrkova, Anastasia;
Tkachuk, Arina;
Khatenkova, Olga;
Balabanian, Linda;
Postovalova, Ekaterina;
Lennerz, Jochen K.;
Meric-Bernstam, Funda;
Bagaev, Alexander

Publication type:

Article

TIPE2 combined with immune cell infiltration predicts prognosis in colorectal cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10449-5

By:

Xia, Hengbo;
Pang, Qingqing;
Xu, Aman;
Hu, Jie

Publication type:

Article

Identification of hub genes within the CCL18 signaling pathway in hepatocellular carcinoma through bioinformatics analysis.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2024.1371990

By:

Mao, Jinlei;
Tao, Yuhang;
Wang, Keke;
Sun, Hanru;
Zhang, Manqi;
Jin, Liang;
Pan, Yi

Publication type:

Article

Extracellular matrix remodeling fibroblasts govern the tumor microenvironment disparity between adenomatous lesions and adenocarcinoma in gallbladder.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1637300

By:

Ma, Chuhan;
Hu, Huixin;
Li, Hanrong;
Han, Bing;
Lv, Chao;
Tian, Yu

Publication type:

Article

Cancer-associated fibroblasts: dual roles from senescence sentinels to death regulators and new dimensions in therapy.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1635771

By:

Ruan, Guixiang;
Wang, Xiang;
Ou, Huiyi;
Guo, Duancheng

Publication type:

Article

Cancer-associated fibroblasts in hepatocellular carcinoma: origins, heterogeneity, and therapeutic implications.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1620075

By:

Shi, Xin;
Zhu, Weixiong;
Zhang, Jianpeng;
Fan, Chuanlei;
Zhang, Jing

Publication type:

Article

Lentinan enhances CAR-T cell potency in solid tumors by optimizing T cell differentiation.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1605488

By:

Niu, Xiangyun;
Zhang, Pengchao;
Liu, Zhongming;
Tang, Yexiao;
Xu, Shu;
Wan, Xiaochun;
Xu, Zhiming;
Zhang, Guizhong

Publication type:

Article

Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1595162

By:

Yang, Yi;
Wu, Yi;
Chen, Hui;
Xu, Zehai;
Lu, Ruisi;
Zhang, Sijie;
Zhan, Rui;
Xi, Qinghua;
Jin, Yunfeng

Publication type:

Article

Hes1 in malignant tumors: from molecular mechanism to therapeutic potential.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1585624

By:

Zhang, Liping;
Zhang, Qian;
Guo, Cheng;
Ru, Zixin;
Yang, Zetian;
Geng, Yi;
Yang, Junjie;
Zhang, Daigui;
Yang, Zhenhuai;
Huang, Shuicai

Publication type:

Article

An immunomodulatory photosensitizer-mediated photodynamic therapy synergizes with PD-L1 blockade against metastatic triple-negative breast cancer.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1651165

By:

Liu, Yuetong;
Wang, Liming;
Kong, Feiyan;
Liu, Tianjun;
Liu, Hong

Publication type:

Article

Uncovering the molecular mechanisms of Qingdu Zengye Decoction in the treatment of nasopharyngeal carcinoma: an integrative investigation.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1648294

By:

Quan, Qi;
Liu, Zeyu;
Ding, Ran;
Lin, Yongmiao;
Zhang, Sihe;
Luo, Wei;
Lei, Mengjie;
Fan, Teng;
Su, Xin;
Huang, Yuanyuan;
Peng, Roujun;
Zhang, Bei

Publication type:

Article

The anticancer activity and mechanisms of She medicine herbs.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1610301

By:

Miao, Yunxuan;
Chen, Yisheng;
Lan, Qiaofen;
Chen, Ruogu;
Zhuang, Jiajia;
Shi, Haojun;
Wang, Miao;
Miao, Jianhui;
Lin, Chengshou

Publication type:

Article

"Molecular pigeon" network of lncRNA and miRNA: decoding metabolic reprogramming in patients with lung cancer.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1578927

By:

Li, Mingxiao;
Dai, Ling;
Chen, Simin;
Deng, Minjie;
Wang, Lihuai;
Sun, Yinhui

Publication type:

Article

Unconventional T cells in anti-cancer immunity.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1618393

By:

Laub, Ariel;
Rodrigues de Almeida, Nathalia;
Huang, Shouxiong

Publication type:

Article

From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1609288

By:

Ye, Hailian;
He, Qi;
Qi, Fang;
Xu, Guangchao;
Qahar, Mulan;
Deng, Chenliang;
Wei, Zairong

Publication type:

Article

Characterization of novel anoikis-related genes as prognostic biomarkers and key determinants of the immune microenvironment in esophageal cancer.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1599171

By:

Su, Yani;
Zhang, Ming;
Xu, Peng;
Wen, Pengfei;
Xu, Ke;
Xie, Jiale;
Wan, Xianjie;
Liu, Lin;
Yang, Zhi;
Yang, Mingyi

Publication type:

Article

Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1589563

By:

Lei, Kai;
Zhao, Yutong;
Li, Shumin;
Liu, Jiawei;
Chen, Wenhao;
Zhou, Caihong;
Zhang, Yi;
Tan, Jinmei;
Wu, Jian;
Zhou, Qi;
Tan, Jiehui

Publication type:

Article

Harnessing immunotherapy: cancer vaccines as novel therapeutic strategies for brain tumor.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1588081

By:

Kiel, Klaudia;
Piranlioglu, Raziye;
Godlewski, Jakub;
Bronisz, Agnieszka

Publication type:

Article

The immune microenvironment in endometrial carcinoma: mechanisms and therapeutic targeting.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1586315

By:

Wang, Yilin;
Liu, Nana;
Guo, Xiangcui;
Han, Ruobing;
Bai, Jin;
Zhong, Jiateng;
Wang, Qianqing

Publication type:

Article

Effect of TP53 mutation, expression and polymorphism on the survival, immune infiltration and ferroptosis in patients with prostate cancer.

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15191

By:

Wen, Gui-Min;
Zhao, Zhen-Ying;
Zheng, Xiao-Hui;
Liu, Da-Hua;
Xia, Pu

Publication type:

Article

Risk score model with two immune infiltration-related long non-coding RNAs to predict prognosis in patients with osteosarcoma.

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15189

By:

Zeng, Ling-Rong;
Zhu, Guang-Hui;
Mei, Hai-Bo;
Yang, Ge

Publication type:

Article

CIAO1 as a crucial signature gene of cuproptosis in gastric cancer.

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15186

By:

Qu, Jiaying;
Yang, Chunhui;
Zhou, Shunchen;
Zhao, Bosen;
Tong, Qiangsong;
Zheng, Liduan

Publication type:

Article

Hepatic artery infusion chemotherapy combined with lenvatinib and PD-1 inhibitors in the treatment of intermediate and advanced unresectable hepatocellular carcinoma.

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15183

By:

Jiang, Peng;
Li, Fengfeng;
Jiang, Zhenyu;
Sun, Yiling;
Yang, Fan;
Chu, Lisha;
Gai, Ya;
Wang, Hongjian

Publication type:

Article

Research progress of anti-angiogenic therapy combined with immunotherapy and radiotherapy for the treatment of brain metastases in non-small cell lung cancer (Review).

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15180

By:

Li, Man;
Gao, Jingyan;
Lu, Fei;
Gong, Chengshu;
Zhang, Jie;
Wang, Li;
Xia, Yaoxiong

Publication type:

Article

Histone lactylation: A new frontier in laryngeal cancer research (Review).

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15167

By:

Tong, Qiaoling;
Huang, Chunsheng;
Tong, Qizhen;
Zhang, Zhiyu

Publication type:

Article

Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non-Appalachian patients.

Published in:

Oncology Letters, 2025, v. 30, n. 3, p. N.PAG, doi. 10.3892/ol.2025.15159

By:

Sougiannis, Alexander T.;
Taylor, Harrison B.;
Zambrzycki, Stephen C.;
Conroy, Lindsey;
Strubler, Rachel;
Edge, Christin;
Drake, Richard R.;
Wallace, Kristin;
Allison, Derek;
Lee, Eun;
Sun, Ramon C.;
Angel, Peggi M.

Publication type:

Article

Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03294-5

By:

Jiang, Zixiong;
Luo, Yu;
Song, Liangdong;
Zhang, Jindong;
Wei, Chengcheng;
Su, Shuai;
Wang, Delin

Publication type:

Article

High Trop-2 expression in pulmonary sarcomatoid carcinoma reveals antibody–drug conjugate targeting Trop-2 is a promising therapeutic approach.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06888-3

By:

Qian, Xiaoying;
Luo, Chuanhong;
Fang, Chen;
Wu, Yongbin;
Hong, Weiwei;
Yu, Biao;
Qin, Guizhen;
Yin, Yan;
Yao, Xinyuan;
Ye, Xin;
Zhou, Bingbiao;
Shu, Chengsi;
Chen, Dengying;
Li, Zhaoqing;
Wang, Shanshan;
Wang, Yong;
Li, Yong

Publication type:

Article

Targeting the Tumor Microenvironment in Hodgkin Lymphoma: Challenges and Therapeutic Strategies.

Published in:

Biocell, 2025, v. 49, n. 7, p. 1185, doi. 10.32604/biocell.2025.063572

By:

Laddaga, Filomena Emanuela;
Pinto, Pamela;
Daraia, Bruna;
D'amato, Antonio;
D'oronzo, Stella;
Martinotti, Stefano;
Gaudio, Francesco

Publication type:

Article

Exercise-induced lactate suppresses ccRCC via CNDP2-mediated depletion of intracellular amino acids.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02609-3

By:

Miao, Rui;
Liu, Chunyan;
Wang, Yilong;
Li, Hui;
Han, Cuihong;
Wang, Chenchen;
Tian, Zhizhen;
Liu, Jiao

Publication type:

Article

Link between multiple human papillomavirus 16 and 18 infection and prostate cancer, and relevance of tumor characteristics.

Published in:

Molecular & Clinical Oncology, 2025, v. 23, n. 3, p. N.PAG, doi. 10.3892/mco.2025.2880

By:

Rodríguez-Romero, Brenda Ivonn;
Pérez-Vielma, Nadia Mabel;
Corzo-Cruz, Alejandro;
Gómez-López, Modesto;
Medel-Flores, María Olivia;
Sánchez-Monroy, Virginia

Publication type:

Article

POSTN is exclusively activated in cancer-associated fibroblasts and leads to unfavorable prognosis of patients with gastric cancer.

Published in:

Molecular & Clinical Oncology, 2025, v. 23, n. 3, p. N.PAG, doi. 10.3892/mco.2025.2877

By:

To, Ching Hei;
Xie, Fuda;
Yu, Peiyao;
Wu, Jialin;
Lyu, Yang;
Chen, Bonan;
Feng, Tiejun;
Leung, Hoi Wing;
Kang, Wei

Publication type:

Article

Single-cell analysis reveals distinct immune characteristics of hepatocellular carcinoma in HBV-positive vs. HBV-negative cases.

Published in:

Molecular & Clinical Oncology, 2025, v. 23, n. 3, p. N.PAG, doi. 10.3892/mco.2025.2871

By:

Liu, Ke;
Chen, Erbao;
Liang, Jiaming;
Li, Yanyan;
Cheng, Binghua;
Shi, Wenli;
Zhou, Zeyu;
Zhou, Wenjie;
Tian, Hui;
Yang, Dongye;
Shao, Ximing;
Li, Hongchang

Publication type:

Article

Histoculture drug response assay predicts chemotherapy efficacy and improves survival in gastrointestinal cancers.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1596253

By:

Wang, Shuang;
Fan, Na;
Li, Han;
Li, Yang;
Hu, Ping;
Chen, Dongliang;
Jiang, Xiaohong;
Gao, Lei;
Yang, Chenggang;
Yang, Dawei

Publication type:

Article

LIN28B promotes the progression of endometrial cancer through upregulating MYC and correlates with immune microenvironment.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1592193

By:

Diao, Yuchao;
Li, Xiangkun;
Wang, Chang;
Jiao, Jinwen;
Gao, Dongmei;
Mao, Weifang;
Yu, Xinping;
Yang, Hongjuan

Publication type:

Article

Advances in extracellular vesicle (EV) biomarkers for precision diagnosis and therapeutic in colorectal cancer.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1581015

By:

Zhang, Li;
Shen, Hui;
Zhang, Nenghua

Publication type:

Article

Integrated multi-omics and machine learning reveal an immunogenic cell death-related signature for prognostic stratification and therapeutic optimization in colorectal cancer.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1606874

By:

Hou, Siyu;
Heng, Shanshan;
Xie, Shaozhuo;
Zhao, Yuanchun;
Chen, Jiajia;
Yu, Chunjiang;
Lin, Yuxin;
Qi, Xin

Publication type:

Article

Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whole-exome and transcriptomic profiling

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1605227

By:

Zeng, Jing;
Li, Qingli;
Li, Kemin;
Yang, Lu;
Xu, Lian;
Wang, Wei;
Yang, Kaixuan;
Wei, Qingbo;
Wang, Jin;
Zhu, Changbin;
Yin, Rutie

Publication type:

Article

Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1589563

By:

Lei, Kai;
Zhao, Yutong;
Li, Shumin;
Liu, Jiawei;
Chen, Wenhao;
Zhou, Caihong;
Zhang, Yi;
Tan, Jinmei;
Wu, Jian;
Zhou, Qi;
Tan, Jiehui

Publication type:

Article

Identification of CTSC-driven progression in ESCC by single-cell sequencing and experimental validation.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1585139

By:

Sui, Xin;
Jia, Yongxu;
Li, Jing;
Xu, Jiayao;
Wang, Wenjia;
Qin, Yanru

Publication type:

Article

Epigenetic modifications in breast cancer: from immune escape mechanisms to therapeutic target discovery.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1584087

By:

Kang, Ziyu;
Wang, Junlin;
Liu, Jiyan;
Du, Li;
Liu, Xiaofei

Publication type:

Article

Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1605055

By:

Wu, Li-Hong;
Yang, Liu;
Wang, Xiang-Xu;
Bai, Shuang;
Yan, Xi;
Wei, Jing;
Wang, Jun;
Tian, Fei

Publication type:

Article