We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?
- Authors
Todenhöfer, Tilman; Hennenlotter, Jörg; Kühs, Ursula; Gerber, Valentina; Gakis, Georgios; Vogel, Ulrich; Aufderklamm, Stefan; Merseburger, Axel; Knapp, Judith; Stenzl, Arnulf; Schwentner, Christian
- Abstract
Preclinical studies demonstrated effects of drugs inhibiting the mevalonate pathway including nitrogen-containing bisphosphonates (N-BPs) and statins on tumor growth and progression. The exact role of this pathway in prostate cancer (PC) has not been identified yet. Herein, we evaluate the expression of farnesyl pyrophosphate synthase (FPPS), the key enzyme of the mevalonate pathway, in PC.
- Publication
World journal of urology, 2013, Vol 31, Issue 2, p345
- ISSN
1433-8726
- Publication type
Journal Article
- DOI
10.1007/s00345-012-0844-y