We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical update on phosphodiesterase type-5 inhibitors for erectile dysfunction.
- Authors
Briganti, Alberto; Salonia, Andrea; Deho', Federico; Zanni, Giuseppe; Barbieri, Luigi; Rigatti, Patrizio; Montorsi, Francesco
- Abstract
Erectile dysfunction (ED) affects the sexual lives of millions of men. The first-line oral pharmacotherapy for most ED patients is phosphodiesterase type-5 (PDE-5) inhibitors, of which three are available. Sildenafil is the most widely prescribed oral agent for ED and has a very satisfactory efficacy-safety profile in all patient categories. Tadalafil and vardenafil were introduced in the European Union and in the United States in 2003 and 2004, respectively. The three PDE-5 inhibitors share many pharmacological and clinical characteristics, and each has unique features. This review, which is based on the contemporary literature on PDE-5 inhibitors, describes the chemical, pharmacological, and clinical features of sildenafil, vardenafil, and tadalafil. The first section reviews the pathophysiology of penile erection and PDE-5 inhibitor pharmacology. The second section summarizes data regarding efficacy and safety of the three drugs in treating ED in the general population as well as in selected patient categories.
- Publication
World journal of urology, 2005, Vol 23, Issue 6, p374
- ISSN
0724-4983
- Publication type
Journal Article
- DOI
10.1007/s00345-005-0022-6