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- Title
High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4.
- Authors
Xia Li; Inoue, Masashi; Reed, Danielle R.; Huque, Taufiqul; Puchalski, Ralph B.; Tordoff, Michael G.; Ninomiya, Yuzo; Beauchamp, Gary K.; Bachmanov, Alexander A.
- Abstract
The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4. A putative sweet taste receptor, T1R1, has been recently cloned, and the gene encoding it, Gpr70, has also been mapped to mouse distal Chr 4. To assess Gpr70 as a candidate gene for Sac, we compared the Gpr70 sequences of C57BL/6ByJ and 129P3/J mouse strains with different alleles of Sac. Using Gpr70 sequence variation between the C57BL/6ByJ and 129P3/J strains, we conducted a high-resolution analysis of the chromosomal localization of the Gpr70 and Sac loci in the F2 hybrids and 129.B6-Sac partially congenic mice originating from these two strains. The Gpr70 gene maps proximal to Sac, which demonstrates that they are different loci.
- Publication
Mammalian Genome, 2001, Vol 12, Issue 1, p13
- ISSN
0938-8990
- Publication type
Academic Journal
- DOI
10.1007/s003350010236