Title

Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort.

Authors

Threadgill, David W.; Hunter, Kent W.; Williams, Robert W.

Abstract

This article focuses on a study related to genetic dissection of complex and quantitative traits. During the previous century, isogenic lines of mice became one of the major resources responsible for advancing biomedical and genetic research. Ken Paigen, director of the Jackson Laboratory, reawakened community interest in the extraordinary genetic resources and phenotypic diversity archived in extant inbred strains. Tracking down complex trait and QTL genes, gene variants that contribute to graded and usually subtle differences among humans and other organisms, is regarded as an exceptionally difficult, if not quixotic task.

Subjects

GENETICS; LABORATORIES; GENES; MICE; MEDICAL research; SURGERY

Publication

Mammalian Genome, 2002, Vol 13, Issue 4, p175

ISSN

0938-8990

Publication type

Academic Journal

DOI

10.1007/s00335-001-4001-Y