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- Title
Interstitial lung disease associated with collagen vascular disorders: disease quantification using a computer-aided diagnosis tool.
- Authors
Marten, K; Dicken, V; Kneitz, C; Höhmann, M; Kenn, W; Hahn, D; Engelke, C
- Abstract
The purpose of this study was to evaluate a computer-aided diagnosis (CAD) tool compared to human observers in quantification of interstitial lung disease (ILD) in patients with collagen-vascular disorders. A total of 52 patients with rheumatoid arthritis (n=24), scleroderma (n=14) and systemic lupus erythematosus (n=14) underwent thin-section CT. Two independent observers assessed the extent of ILD (EoILD), reticulation (EoRet) and ground-glass opacity (EoGGO). CAD assessed EoILD twice. Pulmonary function tests were obtained. Statistical evaluation used 95% limits of agreement and linear regression analysis. CAD correlated well with diffusing capacity (DL(CO)) (R= -0.531, P<0.0001) and moderately with forced vital capacity (FVC) (R= -0.483, P=0.0008). There was close correlation between CAD and the readers (EoILD vs. CAD: R=0.716, P<0.0001; EoRet vs. CAD: R=0.69, P<0.0001). Subgroup analysis including patients with minimal EoGGO (<15%) strengthened the correlations between CAD and the readers, readers and PFT, and CAD and PFT. EoILD by readers correlated strongly with DL(CO) (R= -0.705, P<0.0001) and moderately with FVC (R= -0.559, P=0.0002). EoRet correlated closely with DL(CO) and moderately with FVC (DL(CO): R= -0.663; FVC: R = -0.436; P <or= 0.005). The CAD system is a promising tool for ILD quantification, showing close correlation with human observers and physiologic impairment.
- Publication
European radiology, 2009, Vol 19, Issue 2, p324
- ISSN
1432-1084
- Publication type
Journal Article
- DOI
10.1007/s00330-008-1152-1