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- Title
Therapy with infliximab decreases the CD4+CD28- T cell compartment in peripheral blood in patients with rheumatoid arthritis.
- Authors
Pawlik, Andrzej; Ostanek, Lidia; Brzosko, Iwona; Brzosko, Marek; Masiuk, Marek; Machalinski, Boguslaw; Szklarz, Barbara Gawronska
- Abstract
Chronic inflammatory syndromes such as rheumatoid arthritis (RA) are associated with high frequencies of CD4+CD28- T cells. The number of these cells is genetically determined and may also be a consequence of chronic exposure to tumor necrosis factor-alpha (TNFalpha). The aim of this study was to examine whether the reported efficacy of anti-TNFalpha therapy in RA involves a resurgence of T cell populations that re-express CD28. After 36-week therapy with infliximab, a significant decrease in CD4+CD28- T cells in RA patients was observed in comparison with baseline. The results suggest that TNFalpha-neutralizing therapy may restore T cell homeostasis and reduce expansion of the CD28- T cells, which are cytotoxic and may contribute to organ manifestations in RA.
- Publication
Rheumatology international, 2004, Vol 24, Issue 6, p351
- ISSN
0172-8172
- Publication type
Journal Article
- DOI
10.1007/s00296-003-0374-4