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- Title
Low-molecular-weight, biologically active compounds from marine Pseudoalteromonas species.
- Authors
Kalinovskaya, Nataliya I; Ivanova, Elena P; Alexeeva, Yulia V; Gorshkova, Nataliya M; Kuznetsova, Tatyana A; Dmitrenok, Andrey S; Nicolau, Dan V
- Abstract
We have examined the ability of marine Proteobacteria from the Pseudoalteromonas genus and Alteromonas macleodii to produce low-molecular-weight, biologically active compounds with antimicrobial and surface-active properties. A new marine bacterium, Pseudoalteromonas issachenkonii, exhibited a high level of biological activity and produced antifungal and hemolytic compounds. A detailed spectroscopic investigation based on UV, IR, high-resolution mass spectrometry, and 2D 1H and 13C nuclear magnetic resonance revealed that the former was indole-2,3-dione (isatin). The chemical structure of red-brown pigment (C9H7N3OS3) responsible for hemolytic activity remained unclear. Four of the 15 strains studied (P. luteoviolacea, P. rubra, P. undina, and P. issachenkonii) produced cell-bound, two (P. elaykovii and P. carrageenovora) produced extracellular, and one strain (P. citrea) produced cell-bound and extracellular fatty acids and phospholipids with surface activity. Neither peptides nor glycolipids with surface activity were detected.
- Publication
Current microbiology, 2004, Vol 48, Issue 6, p441
- ISSN
0343-8651
- Publication type
Journal Article
- DOI
10.1007/s00284-003-4240-0