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- Title
Helicobacter pylori infection and gastric carcinogenesis in rodent models.
- Authors
Tsukamoto, Tetsuya; Toyoda, Takeshi; Mizoshita, Tsutomu; Tatematsu, Masae
- Abstract
Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the bacteria exacerbates inflammation and carcinogenesis. Oxygen radical scavengers or anti-inflammatory chemicals as well as eradication of H. pylori are effective to prevent carcinogenesis. H. pylori-associated inflammation induces intestinal metaplasia and intestinalization of stomach cancers independently. It is necessary to control cancer development not only in H. pylori-positive cases but also in H. pylori-negative metaplastic gastritis.
- Publication
Seminars in immunopathology, 2013, Vol 35, Issue 2, p177
- ISSN
1863-2300
- Publication type
Journal Article
- DOI
10.1007/s00281-012-0357-1