We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease?
- Authors
Valenti, Luca; Fracanzani, Anna Ludovica; Fargion, Silvia
- Abstract
Alcoholic liver disease and nonalcoholic liver disease represent a leading cause of liver disease and share similar pathogenic mechanisms among which activation of the immune system plays a key role. The main events consist in (a) activation of Kupffer cells via TLR-4 by LPS and fatty acids (b) complement activation (c) increased release of proinflammatory mediators (d) alteration in NK and NKT cell number/activity (e) activation of the adaptive immune system. At the same time, activation of intracellular pro-inflammatory pathways by cytokines and bacterial products, inhibit insulin signaling favoring lipogenesis, metabolic alterations, and cell damage.
- Publication
Seminars in immunopathology, 2009, Vol 31, Issue 3, p359
- ISSN
1863-2300
- Publication type
Journal Article
- DOI
10.1007/s00281-009-0152-9