We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents.
- Authors
Eilon, G F; Gu, J; Slater, L M; Hara, K; Jacobs, J W
- Abstract
The overall purpose of this study was to determine the potential efficacy of epoxide-containing piperazines as a new class of anti-cancer agents. Two representative compounds, specifically NCO-700, a 4-trimethoxyphenyl-substituted epoxide-piperazine, and TOP-008, a 4-phenylpropenyl-substituted epoxide-piperazine were tested in cytotoxic assays with human breast and prostate cancer cell lines. A second objective was to determine if these two compounds had anti-cancer activity in vivo when tested against xenograft tumors in nude mice or human tumors grown under the kidney capsule in mice. A final objective of this study was to establish if NCO-700 and TOP-008 achieved cancer cell killing through an apoptotic mechanism.
- Publication
Cancer chemotherapy and pharmacology, 2000, Vol 45, Issue 3, p183
- ISSN
0344-5704
- Publication type
Journal Article
- DOI
10.1007/s002800050028