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- Title
A phase I, open-label, mass balance study of [(14)C] dacomitinib (PF-00299804) in healthy male volunteers.
- Authors
Bello, Carlo L; Smith, Evan; Ruiz-Garcia, Ana; Ni, Grace; Alvey, Christine; Loi, Cho-Ming
- Abstract
This study aimed to characterize the primary routes of elimination of the pan-HER tyrosine kinase inhibitor, dacomitinib (PF-00299804), to evaluate the pharmacokinetics of total radioactivity and of dacomitinib and to identify the metabolites of dacomitinib in plasma, urine, and feces in the healthy volunteers.
- Publication
Cancer chemotherapy and pharmacology, 2013, Vol 72, Issue 2, p379
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-013-2207-9