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- Title
Compatibility of intravenous fosaprepitant with intravenous 5-HT3 antagonists and corticosteroids.
- Authors
Sun, Susan; Schaller, Joseph; Placek, Jiri; Duersch, Brett
- Abstract
Fosaprepitant dimeglumine for injection is the water-soluble phosphorylated prodrug of the neurokinin-1 receptor antagonist aprepitant. Both agents are approved (in combination with a 5-HT3 antagonist and a corticosteroid) for prevention of chemotherapy-induced nausea and vomiting. Because fosaprepitant is likely to be combined and stored in the same intravenous (IV) bag with 5-HT3 antagonists and corticosteroids, the in vitro compatibility of fosaprepitant with these agents and other IV diluents was assessed.
- Publication
Cancer chemotherapy and pharmacology, 2013, Vol 72, Issue 3, p509
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-013-2201-2