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- Title
A phase I study of temsirolimus plus carboplatin plus paclitaxel for patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC).
- Authors
Fury, Matthew G; Sherman, Eric; Ho, Alan; Katabi, Nora; Sima, Camelia; Kelly, Katherine W; Nwankwo, Oby; Haque, Sofia; Pfister, David G
- Abstract
The mammalian target of rapamycin complex 1 (mTORC1) is aberrantly activated in many head and neck squamous cell carcinomas (HNSCCs). This phase I study combines the mTORC1 inhibitor temsirolimus with carboplatin and paclitaxel.
- Publication
Cancer chemotherapy and pharmacology, 2012, Vol 70, Issue 1, p121
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-012-1894-y