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- Title
Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study.
- Authors
Minturn, Jane E; Evans, Audrey E; Villablanca, Judith G; Yanik, Gregory A; Park, Julie R; Shusterman, Suzanne; Groshen, Susan; Hellriegel, Edward T; Bensen-Kennedy, Debra; Matthay, Katherine K; Brodeur, Garrett M; Maris, John M
- Abstract
TrkB acts as an oncogenic kinase in a subset of human neuroblastomas. Lestaurtinib, a multi-kinase inhibitor with potent activity against Trk kinases, has demonstrated activity in preclinical models of neuroblastoma.
- Publication
Cancer chemotherapy and pharmacology, 2011, Vol 68, Issue 4, p1057
- ISSN
1432-0843
- Publication type
Journal Article
- DOI
10.1007/s00280-011-1581-4